› 1n3k

Solution NMR

Solution structure of phosphoprotein enriched in astrocytes 15 kDa (PEA-15)

Released:
DOI: 10.2210/pdb1n3k/pdb
PDB entry 1n3k coloured by chain, ensemble of 20 models, front view.
PDB entry 1n3k coloured by chain, ensemble of 20 models, side view.
PDB entry 1n3k coloured by chain, ensemble of 20 models, top view.
Source organism: Cricetulus griseus
Primary publication:
Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain.
Hill JM, Vaidyanathan H, Ramos JW, Ginsberg MH, Werner MH
EMBO J 21 6494-504 (2002)
PMID: 12456656

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195551 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Astrocytic phosphoprotein PEA-15 Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 15.06 KDa
Source organism: Cricetulus griseus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9Z297 (Residues: 1-130; Coverage: 100%)
Gene name: PEA15
Sequence domains: Death effector domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

15 review citations

ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence.
Cagnol et al. (2010)
14 more

3 mentions without citation

Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain.
Hill et al. (2002)
2 more