› 1n7e

X-ray diffraction
1.5Å resolution

Crystal structure of the sixth PDZ domain of GRIP1

Released:
DOI: 10.2210/pdb1n7e/pdb
PDB entry 1n7e coloured by chain, front view.
PDB entry 1n7e coloured by chain, side view.
PDB entry 1n7e coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of GRIP1 PDZ6-peptide complex reveals the structural basis for class II PDZ target recognition and PDZ domain-mediated multimerization.
Im YJ, Park SH, Rho SH, Lee JH, Kang GB, Sheng M, Kim E, Eom SH
J Biol Chem 278 8501-7 (2003)
PMID: 12493751

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161335 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor-interacting protein 1 Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 10.14 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P97879 (Residues: 665-761; Coverage: 9%)
Gene name: Grip1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P6522
Unit cell:
a: 40.267Å b: 40.267Å c: 222.872Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.256 0.254 0.278
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

PDZ domain proteins of synapses.
Kim et al. (2004)
8 more

14 mentions without citation

Emerging Themes in PDZ Domain Signaling: Structure, Function, and Inhibition.
Liu et al. (2019)
13 more