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Solution NMR

NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles

Released:
DOI: 10.2210/pdb1nau/pdb
PDB entry 1nau coloured by chain, ensemble of 16 models, front view.
PDB entry 1nau coloured by chain, ensemble of 16 models, side view.
PDB entry 1nau coloured by chain, ensemble of 16 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR solution structure of the glucagon antagonist [desHis1, desPhe6, Glu9]glucagon amide in the presence of perdeuterated dodecylphosphocholine micelles.
Ying J, Ahn JM, Jacobsen NE, Brown MF, Hruby VJ
Biochemistry 42 2825-35 (2003)
PMID: 12627948

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134154 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucagon Chain: A
Molecule details ›
Chain: A
Length: 28 amino acids
Theoretical weight: 3.21 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01275 (Residues: 54-81; Coverage: 17%)
Gene name: GCG
Sequence domains: Peptide hormone

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, restrained molecular dynamics
Expression system: Not provided

Quick links

Citations

3 review citations

Membrane catalysis of peptide-receptor binding.
Langelaan et al. (2010)
2 more

2 mentions without citation

The nature of amyloid-like glucagon fibrils.
Pedersen JS. (2010)
1 more