› 1nbq

X-ray diffraction
2.9Å resolution

Crystal Structure of Human Junctional Adhesion Molecule Type 1

Released:
DOI: 10.2210/pdb1nbq/pdb
PDB entry 1nbq coloured by chain, front view.
PDB entry 1nbq coloured by chain, side view.
PDB entry 1nbq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding.
Prota AE, Campbell JA, Schelling P, Forrest JC, Watson MJ, Peters TR, Aurrand-Lions M, Imhof BA, Dermody TS, Stehle T
Proc Natl Acad Sci U S A 100 5366-71 (2003)
PMID: 12697893

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195333 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Junctional adhesion molecule A Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 22.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y624 (Residues: 27-233; Coverage: 76%)
Gene names: F11R, JAM1, JCAM, UNQ264/PRO301
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2
Unit cell:
a: 116.8Å b: 61.8Å c: 82.9Å
α: 90° β: 120.01° γ: 90°
R-values:
R R work R free
0.22 0.22 0.305
Expression system: Escherichia coli

Quick links

Citations

33 review citations

Platelets as immune cells: bridging inflammation and cardiovascular disease.
von Hundelshausen et al. (2007)
32 more

11 mentions without citation

Immunoglobulin superfamily virus receptors and the evolution of adaptive immunity.
Dermody et al. (2009)
10 more