› 1ncj

X-ray diffraction
3.4Å resolution

N-CADHERIN, TWO-DOMAIN FRAGMENT

Released:
DOI: 10.2210/pdb1ncj/pdb
PDB entry 1ncj coloured by chain, front view.
PDB entry 1ncj coloured by chain, side view.
PDB entry 1ncj coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure-function analysis of cell adhesion by neural (N-) cadherin.
Tamura K, Shan WS, Hendrickson WA, Colman DR, Shapiro L
Neuron 20 1153-63 (1998)
PMID: 9655503

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-2 Chain: A
Molecule details ›
Chain: A
Length: 215 amino acids
Theoretical weight: 23.6 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P15116 (Residues: 160-374; Coverage: 24%)
Gene name: Cdh2
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

2 bound ligands:
Ligand CA 3 x CA
Ligand IUM 1 x IUM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: I422
Unit cell:
a: 99Å b: 99Å c: 136.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.212 0.321
Expression system: Escherichia coli

Quick links

Citations

55 review citations

Regulation of cadherin-mediated adhesion in morphogenesis.
Gumbiner BM. (2005)
54 more

9 mentions without citation

Bacillus thuringiensis: a genomics and proteomics perspective.
Ibrahim et al. (2010)
8 more