› 1nco

X-ray diffraction
1.8Å resolution

STRUCTURE OF THE ANTITUMOR PROTEIN-CHROMOPHORE COMPLEX NEOCARZINOSTATIN

Released:
DOI: 10.2210/pdb1nco/pdb
PDB entry 1nco coloured by chain, front view.
PDB entry 1nco coloured by chain, side view.
PDB entry 1nco coloured by chain, top view.
Source organism: Streptomyces carzinostaticus
Primary publication:
Crystal structure of neocarzinostatin, an antitumor protein-chromophore complex.
Kim KH, Kwon BM, Myers AG, Rees DC
Science 262 1042-6 (1993)
PMID: 8235619

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141218 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neocarzinostatin Chains: A, B
Molecule details ›
Chains: A, B
Length: 113 amino acids
Theoretical weight: 11.1 KDa
Source organism: Streptomyces carzinostaticus
Expression system: Not provided
UniProt:
  • Canonical: P0A3R9 (Residues: 35-147; Coverage: 100%)
Gene name: ncsA
Sequence domains: Neocarzinostatin family
Structure domains: Neocarzinostatin-like

Ligands and Environments

2 bound ligands:
Ligand MRD 1 x MRD
Ligand CHR 1 x CHR
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P65
Unit cell:
a: 90.4Å b: 90.4Å c: 52.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 not available not available
Expression system: Not provided

Quick links

Citations

3 review citations

Probing the biology of natural products: molecular editing by diverted total synthesis.
Szpilman et al. (2010)
2 more

7 mentions without citation

LIGSITEcsc: predicting ligand binding sites using the Connolly surface and degree of conservation.
Huang et al. (2006)
6 more