› 1niv

X-ray diffraction
3Å resolution

MANNOSE-SPECIFIC AGGLUTININ (LECTIN) FROM SNOWDROP (GALANTHUS NIVALIS) BULBS IN COMPLEX WITH MANNOSE-ALPHA 1,3-METHYL-D-MANNOSE

Released:
DOI: 10.2210/pdb1niv/pdb
PDB entry 1niv coloured by chain, front view.
PDB entry 1niv coloured by chain, side view.
PDB entry 1niv coloured by chain, top view.
Source organism: Galanthus nivalis
Primary publication:
The mannose-specific bulb lectin from Galanthus nivalis (snowdrop) binds mono- and dimannosides at distinct sites. Structure analysis of refined complexes at 2.3 A and 3.0 A resolution.
Hester G, Wright CS
J Mol Biol 262 516-31 (1996)
PMID: 8893860

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151772 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Mannose-specific lectin Chains: A, C
Molecule details ›
Chains: A, C
Length: 109 amino acids
Theoretical weight: 12.06 KDa
Source organism: Galanthus nivalis
UniProt:
  • Canonical: P30617 (Residues: 24-132; Coverage: 79%)
Structure domains: Bulb-type lectin domain

Ligands and Environments

Carbohydrate polymer : NEW Components: MMA, MAN
Carbohydrate polymer
1 bound ligand:
Ligand MMA 3 x MMA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I213
Unit cell:
a: 138.149Å b: 138.149Å c: 138.149Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.227 0.269

Quick links

Citations

6 review citations

Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy.
Balzarini J. (2007)
5 more

4 mentions without citation

Antiviral lectins: Selective inhibitors of viral entry.
Mitchell et al. (2017)
3 more