› 1nk1

X-ray diffraction
2.5Å resolution

NK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR/SCATTER FACTOR (HGF/SF) AT 2.5 ANGSTROM RESOLUTION

Released:
DOI: 10.2210/pdb1nk1/pdb
PDB entry 1nk1 coloured by chain, front view.
PDB entry 1nk1 coloured by chain, side view.
PDB entry 1nk1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding.
Chirgadze DY, Hepple JP, Zhou H, Byrd RA, Blundell TL, Gherardi E
Nat Struct Biol 6 72-9 (1999)
PMID: 9886295

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146878 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor alpha chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 183 amino acids
Theoretical weight: 21.17 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P14210 (Residues: 28-210; Coverage: 26%)
Gene names: HGF, HPTA
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.5
Spacegroup: P21
Unit cell:
a: 53.42Å b: 63.56Å c: 56.81Å
α: 90° β: 96.04° γ: 90°
R-values:
R R work R free
0.245 0.245 0.319
Expression system: Komagataella pastoris

Quick links

Citations

13 review citations

Met, metastasis, motility and more.
Birchmeier et al. (2003)
12 more

12 mentions without citation

MET: a critical player in tumorigenesis and therapeutic target.
Graveel et al. (2013)
11 more