› 1nn2

X-ray diffraction
2.2Å resolution

THREE-DIMENSIONAL STRUCTURE OF THE NEURAMINIDASE OF INFLUENZA VIRUS A(SLASH)TOKYO(SLASH)3(SLASH)67 AT 2.2 ANGSTROMS RESOLUTION

Released:
DOI: 10.2210/pdb1nn2/pdb
PDB entry 1nn2 coloured by chain, front view.
PDB entry 1nn2 coloured by chain, side view.
PDB entry 1nn2 coloured by chain, top view.
Source organism: Influenza A virus (A/Tokyo/3/1967(H2N2))
Primary publication:
Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 A resolution.
Varghese JN, Colman PM
J Mol Biol 221 473-86 (1991)
PMID: 1920428

Function and Biology Details

Reaction catalysed: 
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139246 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Neuraminidase Chain: A
Molecule details ›
Chain: A
Length: 388 amino acids
Theoretical weight: 43.14 KDa
Source organism: Influenza A virus (A/Tokyo/3/1967(H2N2))
Expression system: Not provided
UniProt:
  • Canonical: P06820 (Residues: 82-469; Coverage: 83%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, NGK, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I422
Unit cell:
a: 139.6Å b: 139.6Å c: 191Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 not available
Expression system: Not provided

Quick links

Citations

22 review citations

Influenza virus neuraminidase inhibitors.
Gubareva et al. (2000)
21 more

29 mentions without citation

Function and 3D structure of the N-glycans on glycoproteins.
Nagae et al. (2012)
28 more