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› 1ntz

X-ray diffraction
2.6Å resolution

Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone

Released:
DOI: 10.2210/pdb1ntz/pdb
Model geometry
Fit model/data
Data not deposited
PDB entry 1ntz coloured by chain, front view.
PDB entry 1ntz coloured by chain, side view.
PDB entry 1ntz coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structural basis for the quinone reduction in the bc1 complex: a comparative analysis of crystal structures of mitochondrial cytochrome bc1 with bound substrate and inhibitors at the Qi site.
Gao X, Wen X, Esser L, Quinn B, Yu L, Yu CA, Xia D
Biochemistry 42 9067-80 (2003)
PMID: 12885240

Function and Biology Details

Reaction catalysed: 
a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero 22-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132263 (preferred)
Entry contents:
11 distinct polypeptide molecules
Macromolecules (11 distinct):
Cytochrome b-c1 complex subunit 1, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 446 amino acids
Theoretical weight: 49.27 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P31800 (Residues: 35-480; Coverage: 93%)
Gene name: UQCRC1
Sequence domains:
Structure domains: Metalloenzyme, LuxS/M16 peptidase-like
Cytochrome b-c1 complex subunit 2, mitochondrial Chain: B
Molecule details ›
Chain: B
Length: 439 amino acids
Theoretical weight: 46.58 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P23004 (Residues: 15-453; Coverage: 97%)
Gene name: UQCRC2
Sequence domains:
Structure domains: Metalloenzyme, LuxS/M16 peptidase-like
Cytochrome b Chain: C
Cytochrome c1, heme protein, mitochondrial Chain: D
Cytochrome b-c1 complex subunit Rieske, mitochondrial Chain: E
Cytochrome b-c1 complex subunit 7 Chain: F
Cytochrome b-c1 complex subunit 8 Chain: G
Cytochrome b-c1 complex subunit 6, mitochondrial Chain: H
Cytochrome b-c1 complex subunit 9 Chain: I
Cytochrome b-c1 complex subunit 9 Chain: J
Cytochrome b-c1 complex subunit 10 Chain: K

Ligands and Environments


Cofactor: Ligand UQ2 2 x UQ2

Cofactor: Ligand HEM 3 x HEM
1 bound ligand:
Ligand FES 1 x FES
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS BEAMLINE X9B
Spacegroup: I4122
Unit cell:
a: 153.828Å b: 153.828Å c: 596.671Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.247 0.283

Quick links

Citations

23 review citations

The cytochrome bc1 complex: function in the context of structure.
Crofts AR. (2004)
22 more

19 mentions without citation

The Q cycle of cytochrome bc complexes: a structure perspective.
Cramer et al. (2011)
18 more