› 1nzm

Solution NMR

NMR structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 complexed with the telomerase inhibitor RHPS4

Released:
DOI: 10.2210/pdb1nzm/pdb
PDB entry 1nzm coloured by chain, ensemble of 10 models, front view.
PDB entry 1nzm coloured by chain, ensemble of 10 models, side view.
PDB entry 1nzm coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Drug recognition and stabilisation of the parallel-stranded DNA quadruplex d(TTAGGGT)4 containing the human telomeric repeat.
Gavathiotis E, Heald RA, Stevens MF, Searle MS
J Mol Biol 334 25-36 (2003)
PMID: 14596797

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114290 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*TP*TP*AP*GP*GP*GP*T)-3' Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 7 nucleotides
Theoretical weight: 2.17 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand K 2 x K
Ligand LG1 2 x LG1
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Restrained molecular dynamics
Expression system: Not provided

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Citations

18 review citations

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
17 more

9 mentions without citation

Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches.
Carabet et al. (2018)
8 more