› 1nzn

X-ray diffraction
2Å resolution

Cytosolic domain of the human mitchondrial fission protein Fis1 adopts a TPR fold

Released:
DOI: 10.2210/pdb1nzn/pdb
PDB entry 1nzn coloured by chain, front view.
PDB entry 1nzn coloured by chain, side view.
PDB entry 1nzn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold.
Dohm JA, Lee SJ, Hardwick JM, Hill RB, Gittis AG
Proteins 54 153-6 (2004)
PMID: 14705031

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-195199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial fission 1 protein Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y3D6 (Residues: 1-123; Coverage: 81%)
Gene names: CGI-135, FIS1, TTC11
Sequence domains:
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand GOL 1 x GOL
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6522
Unit cell:
a: 48.985Å b: 48.985Å c: 169.199Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.23 0.23 0.255
Expression system: Escherichia coli

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Citations

25 review citations

Mitochondrial dynamics and apoptosis.
Suen et al. (2008)
24 more

13 mentions without citation

Mitochondrial quality control in the brain: The physiological and pathological roles.
Shen et al. (2022)
12 more