› 1o3x

X-ray diffraction
2.1Å resolution

Crystal structure of human GGA1 GAT domain

Released:
DOI: 10.2210/pdb1o3x/pdb
PDB entry 1o3x coloured by chain, front view.
PDB entry 1o3x coloured by chain, side view.
PDB entry 1o3x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport.
Shiba T, Kawasaki M, Takatsu H, Nogi T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Nakayama K, Wakatsuki S
Nat Struct Biol 10 386-93 (2003)
PMID: 12679809

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193827 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosylation factor-binding protein GGA1 Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UJY5 (Residues: 166-305; Coverage: 22%)
Gene name: GGA1
Sequence domains:
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-18B
Spacegroup: R3
Unit cell:
a: 85.11Å b: 85.11Å c: 59.001Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.245 0.29
Expression system: Escherichia coli BL21

Quick links

Citations

23 review citations

ARF proteins: roles in membrane traffic and beyond.
D'Souza-Schorey et al. (2006)
22 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)