› 1o5p

Solution NMR

Solution Structure of holo-Neocarzinostatin

Released:
DOI: 10.2210/pdb1o5p/pdb
PDB entry 1o5p coloured by chain, ensemble of 60 models, front view.
PDB entry 1o5p coloured by chain, ensemble of 60 models, side view.
PDB entry 1o5p coloured by chain, ensemble of 60 models, top view.
Source organism: Streptomyces carzinostaticus
Primary publication:
Solution NMR structure investigation for releasing mechanism of neocarzinostatin chromophore from the holoprotein.
Takashima H, Yoshida T, Ishino T, Hasuda K, Ohkubo T, Kobayashi Y
J Biol Chem 280 11340-6 (2005)
PMID: 15640161

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141217 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neocarzinostatin Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 11.1 KDa
Source organism: Streptomyces carzinostaticus
UniProt:
  • Canonical: P0A3R9 (Residues: 35-147; Coverage: 100%)
Gene name: ncsA
Sequence domains: Neocarzinostatin family
Structure domains: Neocarzinostatin-like

Ligands and Environments

1 bound ligand:
Ligand CHR 1 x CHR
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing with random array initial structures

Quick links

Citations

1 review citation

Complexity and simplicity in the biosynthesis of enediyne natural products.
Liang ZX. (2010)
7 other articles

1 mention without citation

Evaluating the use of Apo-neocarzinostatin as a cell penetrating protein.
Moody et al. (2013)