› 1o7f

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF EPAC2

Released:
DOI: 10.2210/pdb1o7f/pdb
PDB entry 1o7f coloured by chain, front view.
PDB entry 1o7f coloured by chain, side view.
PDB entry 1o7f coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure and regulation of the cAMP-binding domains of Epac2.
Rehmann H, Prakash B, Wolf E, Rueppel A, de Rooij J, Bos JL, Wittinghofer A
Nat Struct Biol 10 26-32 (2003)
PMID: 12469113

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rap guanine nucleotide exchange factor 4 Chain: A
Molecule details ›
Chain: A
Length: 469 amino acids
Theoretical weight: 53.27 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9EQZ6 (Residues: 1-481; Coverage: 46%)
Gene names: Cgef2, Epac2, Rapgef4
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 67.429Å b: 96.062Å c: 103.776Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.244 0.278
Expression system: Escherichia coli

Quick links

Citations

31 review citations

Localized effects of cAMP mediated by distinct routes of protein kinase A.
Taskén et al. (2004)
30 more

5 mentions without citation

Cyclic nucleotide binding proteins in the Arabidopsis thaliana and Oryza sativa genomes.
Bridges et al. (2005)
4 more