› 1o7y

X-ray diffraction
3Å resolution

Crystal structure of IP-10 M-form

Released:
DOI: 10.2210/pdb1o7y/pdb
PDB entry 1o7y coloured by chain, front view.
PDB entry 1o7y coloured by chain, side view.
PDB entry 1o7y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine.
Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR
Structure 11 521-32 (2003)
PMID: 12737818

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136206 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-X-C motif chemokine 10 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 77 amino acids
Theoretical weight: 8.64 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02778 (Residues: 22-98; Coverage: 100%)
Gene names: CXCL10, INP10, SCYB10
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: C2
Unit cell:
a: 138.979Å b: 53.722Å c: 53.366Å
α: 90° β: 105.72° γ: 90°
R-values:
R R work R free
0.267 0.267 0.309
Expression system: Not provided

Quick links

Citations

15 review citations

Chemokine: receptor structure, interactions, and antagonism.
Allen et al. (2007)
14 more

12 mentions without citation

The marriage of chemokines and galectins as functional heterodimers.
von Hundelshausen et al. (2021)
11 more