› 1o8r

Solution NMR

Solution structure of human proguanylin

Released:
DOI: 10.2210/pdb1o8r/pdb
PDB entry 1o8r coloured by chain, ensemble of 30 models, front view.
PDB entry 1o8r coloured by chain, ensemble of 30 models, side view.
PDB entry 1o8r coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of human proguanylin: the role of a hormone prosequence.
Lauber T, Neudecker P, Rösch P, Marx UC
J Biol Chem 278 24118-24 (2003)
PMID: 12707255

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169743 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanylin Chain: A
Molecule details ›
Chain: A
Length: 94 amino acids
Theoretical weight: 10.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02747 (Residues: 22-115; Coverage: 100%)
Gene names: GUCA2, GUCA2A
Sequence domains: Guanylin precursor
Structure domains: Guanylin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

4 review citations

Recognition and signal transduction mechanism of Escherichia coli heat-stable enterotoxin and its receptor, guanylate cyclase C.
Hasegawa et al. (2005)
3 more

4 mentions without citation

Protein structure prediction using sparse dipolar coupling data.
Qu et al. (2004)
3 more