› 1o8y

Solution NMR

Solution structure of SFTI-1(6,5), an acyclic permutant of the proteinase inhibitor SFTI-1, trans-trans-trans conformer (tt-A)

Released:
DOI: 10.2210/pdb1o8y/pdb
PDB entry 1o8y coloured by chain, ensemble of 20 models, front view.
PDB entry 1o8y coloured by chain, ensemble of 20 models, side view.
PDB entry 1o8y coloured by chain, ensemble of 20 models, top view.
Source organism: Helianthus annuus
Primary publication:
Enzymatic cyclization of a potent bowman-birk protease inhibitor, sunflower trypsin inhibitor-1, and solution structure of an acyclic precursor peptide.
Marx UC, Korsinczky ML, Schirra HJ, Jones A, Condie B, Otvos L, Craik DJ
J Biol Chem 278 21782-9 (2003)
PMID: 12621047

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175541 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trypsin inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 14 amino acids
Theoretical weight: 1.54 KDa
Source organism: Helianthus annuus
Expression system: Not provided
UniProt:
  • Canonical: Q4GWU5 (Residues: 40-53; Coverage: 45%)
Gene name: sfti1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

13 review citations

Cyclotides, a novel ultrastable polypeptide scaffold for drug discovery.
Gould et al. (2011)
12 more