› 1o9m

X-ray diffraction
2.4Å resolution

The Complex of a novel antibiotic with the Aminoacyl Site of the Bacterial Ribosome Revealed by X-Ray Crystallography.

Released:
DOI: 10.2210/pdb1o9m/pdb
PDB entry 1o9m coloured by chain, front view.
PDB entry 1o9m coloured by chain, side view.
PDB entry 1o9m coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography.
Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S
J Am Chem Soc 125 3410-1 (2003)
PMID: 12643685

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196151 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
EUBACTERIAL A-SITE Chains: A, B
Molecule details ›
Chains: A, B
Length: 22 nucleotides
Theoretical weight: 7.05 KDa
Source organism: Escherichia coli
Expression system: Not provided

Ligands and Environments

4 bound ligands:
Ligand BDG 1 x BDG
Ligand PA2 1 x PA2
Ligand P24 1 x P24
Ligand 42B 1 x 42B
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 32.8Å b: 46.55Å c: 88.81Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.251 0.298
Expression system: Not provided

Quick links

Citations

13 review citations

Multi-targeting by monotherapeutic antibacterials.
Silver LL. (2007)
12 more

5 mentions without citation

Three-dimensional motifs from the SCOR, structural classification of RNA database: extruded strands, base triples, tetraloops and U-turns.
Klosterman et al. (2004)
4 more