› 1oa8

X-ray diffraction
1.7Å resolution

AXH domain of human spinocerebellar ataxin-1

Released:
DOI: 10.2210/pdb1oa8/pdb
PDB entry 1oa8 coloured by chain, front view.
PDB entry 1oa8 coloured by chain, side view.
PDB entry 1oa8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the AXH domain of spinocerebellar ataxin-1.
Chen YW, Allen MD, Veprintsev DB, Löwe J, Bycroft M
J Biol Chem 279 3758-65 (2004)
PMID: 14583607

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156967 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ataxin-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 133 amino acids
Theoretical weight: 14.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54253 (Residues: 561-693; Coverage: 16%)
Gene names: ATX1, ATXN1, SCA1
Sequence domains: Ataxin-1 and HBP1 module (AXH)

Ligands and Environments

1 bound ligand:
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P212121
Unit cell:
a: 48.783Å b: 82.441Å c: 137.781Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.252
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Pathogenic mechanisms of a polyglutamine-mediated neurodegenerative disease, spinocerebellar ataxia type 1.
Zoghbi et al. (2009)
8 more

7 mentions without citation

Kaleidoscopic protein-protein interactions in the life and death of ataxin-1: new strategies against protein aggregation.
de Chiara et al. (2014)
6 more