› 1oed

Electron Microscopy
4Å resolution

STRUCTURE OF ACETYLCHOLINE RECEPTOR PORE FROM ELECTRON IMAGES

Released:
DOI: 10.2210/pdb1oed/pdb
PDB entry 1oed coloured by chain, front view.
PDB entry 1oed coloured by chain, side view.
PDB entry 1oed coloured by chain, top view.
Source organism: Torpedo marmorata
Primary publication:
Structure and gating mechanism of the acetylcholine receptor pore.
Miyazawa A, Fujiyoshi Y, Unwin N
Nature 423 949-55 (2003)
PMID: 12827192
Related structures: EMD-1044

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136095 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Acetylcholine receptor subunit alpha Chains: A, D
Molecule details ›
Chains: A, D
Length: 227 amino acids
Theoretical weight: 25.39 KDa
Source organism: Torpedo marmorata
UniProt:
  • Canonical: P02711 (Residues: 235-461; Coverage: 52%)
Gene name: CHRNA1
Sequence domains: Neurotransmitter-gated ion-channel transmembrane region
Structure domains: Neurotransmitter-gated ion-channel transmembrane domain
Acetylcholine receptor subunit beta Chain: B
Molecule details ›
Chain: B
Length: 250 amino acids
Theoretical weight: 28.39 KDa
Source organism: Torpedo marmorata
UniProt:
  • Canonical: P02712 (Residues: 241-490; Coverage: 53%)
Gene name: CHRNB1
Sequence domains: Neurotransmitter-gated ion-channel transmembrane region
Structure domains: Neurotransmitter-gated ion-channel transmembrane domain
Acetylcholine receptor subunit delta Chain: C
Molecule details ›
Chain: C
Length: 260 amino acids
Theoretical weight: 29.37 KDa
Source organism: Torpedo marmorata
UniProt:
  • Canonical: P02718 (Residues: 246-505; Coverage: 52%)
Gene name: chrnd
Sequence domains: Neurotransmitter-gated ion-channel transmembrane region
Structure domains: Neurotransmitter-gated ion-channel transmembrane domain
Acetylcholine receptor subunit gamma Chain: E
Molecule details ›
Chain: E
Length: 260 amino acids
Theoretical weight: 29.32 KDa
Source organism: Torpedo marmorata
UniProt:
  • Canonical: P02714 (Residues: 236-495; Coverage: 53%)
Gene name: CHRNG
Sequence domains: Neurotransmitter-gated ion-channel transmembrane region
Structure domains: Neurotransmitter-gated ion-channel transmembrane domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-1044

Quick links

Citations

189 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
188 more

39 mentions without citation

Mammalian nicotinic acetylcholine receptors: from structure to function.
Albuquerque et al. (2009)
38 more