› 1oht

X-ray diffraction
2Å resolution

Peptidoglycan recognition protein LB

Released:
DOI: 10.2210/pdb1oht/pdb
PDB entry 1oht coloured by chain, front view.
PDB entry 1oht coloured by chain, side view.
PDB entry 1oht coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster.
Kim MS, Byun M, Oh BH
Nat Immunol 4 787-93 (2003)
PMID: 12845326

Function and Biology Details

Reaction catalysed: 
Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184830 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidoglycan-recognition protein LB Chain: A
Molecule details ›
Chain: A
Length: 215 amino acids
Theoretical weight: 23.96 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8INK6 (Residues: 18-232; Coverage: 99%)
Gene names: CG14704, PGRP-LB
Sequence domains: N-acetylmuramoyl-L-alanine amidase
Structure domains: Peptidoglycan recognition protein-like

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand EDO 2 x EDO
Ligand TLA 1 x TLA
1 modified residue:
Ligand MSE 7 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P6122
Unit cell:
a: 40.561Å b: 40.561Å c: 337.997Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.216 0.243
Expression system: Escherichia coli

Quick links

Citations

28 review citations

The host defense of Drosophila melanogaster.
Lemaitre et al. (2007)
27 more

7 mentions without citation

The peptidoglycan recognition proteins (PGRPs).
Dziarski et al. (2006)
6 more