› 1oi1

X-ray diffraction
1.78Å resolution

Crystal Structure of the MBT domains of Human SCML2

Released:
DOI: 10.2210/pdb1oi1/pdb
PDB entry 1oi1 coloured by chain, front view.
PDB entry 1oi1 coloured by chain, side view.
PDB entry 1oi1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the malignant brain tumor (MBT) repeats in Sex Comb on Midleg-like 2 (SCML2).
Sathyamurthy A, Allen MD, Murzin AG, Bycroft M
J Biol Chem 278 46968-73 (2003)
PMID: 12952983

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194074 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sex comb on midleg-like protein 2 Chain: A
Molecule details ›
Chain: A
Length: 221 amino acids
Theoretical weight: 24.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UQR0 (Residues: 23-243; Coverage: 32%)
Gene name: SCML2
Sequence domains: mbt repeat
Structure domains: SH3 type barrels.

Ligands and Environments

1 bound ligand:
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 118.762Å b: 47.696Å c: 41.493Å
α: 90° β: 100.29° γ: 90°
R-values:
R R work R free
0.171 0.171 0.204
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Readout of epigenetic modifications.
Patel et al. (2013)
7 more

2 mentions without citation

Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg.
Grimm et al. (2007)
1 more