› 1oiw

X-ray diffraction
2.05Å resolution

X-ray structure of the small G protein Rab11a in complex with GTPgammaS

Released:
DOI: 10.2210/pdb1oiw/pdb
PDB entry 1oiw coloured by chain, front view.
PDB entry 1oiw coloured by chain, side view.
PDB entry 1oiw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural GDP/GTP cycle of Rab11 reveals a novel interface involved in the dynamics of recycling endosomes.
Pasqualato S, Senic-Matuglia F, Renault L, Goud B, Salamero J, Cherfils J
J Biol Chem 279 11480-8 (2004)
PMID: 14699104

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158623 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-11A Chain: A
Molecule details ›
Chain: A
Length: 191 amino acids
Theoretical weight: 21.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62491 (Residues: 1-173; Coverage: 80%)
Gene names: RAB11, RAB11A
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand GSP 1 x GSP
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: I422
Unit cell:
a: 73.726Å b: 73.726Å c: 125.152Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.265 0.265 0.285
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Orchestration of cell surface proteins by Rab11.
Welz et al. (2014)
8 more

11 mentions without citation

Rab GTPases and their interacting protein partners: Structural insights into Rab functional diversity.
Pylypenko et al. (2018)
10 more