› 1ok0

X-ray diffraction
0.93Å resolution

Crystal Structure of Tendamistat

Released:
DOI: 10.2210/pdb1ok0/pdb
PDB entry 1ok0 coloured by chain, front view.
PDB entry 1ok0 coloured by chain, side view.
PDB entry 1ok0 coloured by chain, top view.
Source organism: Streptomyces tendae
Primary publication:
Structure of the alpha-amylase inhibitor tendamistat at 0.93 A.
König V, Vértesy L, Schneider TR
Acta Crystallogr D Biol Crystallogr 59 1737-43 (2003)
PMID: 14501112

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133937 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-amylase inhibitor HOE-467A Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 7.97 KDa
Source organism: Streptomyces tendae
UniProt:
  • Canonical: P01092 (Residues: 31-104; Coverage: 100%)
Sequence domains: Alpha amylase inhibitor
Structure domains: Alpha-amylase inhibitor

Ligands and Environments

2 bound ligands:
Ligand GOL 2 x GOL
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P212121
Unit cell:
a: 25.68Å b: 40.78Å c: 60.95Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.103 not available 0.13

Quick links

Citations

1 citations in other articles

Potent Human α-Amylase Inhibition by the β-Defensin-like Protein Helianthamide.
Tysoe et al. (2016)

16 mentions without citation

Miniproteins as phage display-scaffolds for clinical applications.
Zoller et al. (2011)
15 more