1oln

Hybrid

Model for thiostrepton antibiotic binding to L11 substrate from 50S ribosomal RNA

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-143179 (preferred)
Entry contents:
2 distinct polypeptide molecules
1 distinct RNA molecule
Macromolecules (3 distinct):
Large ribosomal subunit protein uL11 Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 14.98 KDa
Source organism: Thermotoga maritima
UniProt:
  • Canonical: P29395 (Residues: 2-141; Coverage: 99%)
Gene names: TM_0454, rplK
Sequence domains:
Thiostrepton Chain: B
Molecule details ›
Chain: B
Length: 19 amino acids
Theoretical weight: 1.81 KDa
Source organism: Streptomyces azureus
UniProt:
  • Canonical: P0C8P8 (Residues: 56-72; Coverage: 24%)
Gene name: tpdA
RNA Chain: C
Molecule details ›
Chain: C
Length: 58 nucleotides
Theoretical weight: 18.69 KDa
Sequence domains: Bacterial large subunit ribosomal RNA

Ligands and Environments

No bound ligands

Experiments and Validation Details

Experimental Method: Solution NMR, Theoretical Model