› 1olz

X-ray diffraction
2Å resolution

The ligand-binding face of the semaphorins revealed by the high resolution crystal structure of SEMA4D

Released:
DOI: 10.2210/pdb1olz/pdb
PDB entry 1olz coloured by chain, front view.
PDB entry 1olz coloured by chain, side view.
PDB entry 1olz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D.
Love CA, Harlos K, Mavaddat N, Davis SJ, Stuart DI, Jones EY, Esnouf RM
Nat Struct Biol 10 843-8 (2003)
PMID: 12958590

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187785 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Semaphorin-4D Chains: A, B
Molecule details ›
Chains: A, B
Length: 663 amino acids
Theoretical weight: 74.32 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q92854 (Residues: 22-678; Coverage: 78%)
Gene names: C9orf164, CD100, SEMA4D, SEMAJ
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P1
Unit cell:
a: 73.32Å b: 76.76Å c: 89.41Å
α: 77.41° β: 73.35° γ: 63.57°
R-values:
R R work R free
0.206 0.206 0.27
Expression system: Cricetulus griseus

Quick links

Citations

43 review citations

Semaphorins command cells to move.
Kruger et al. (2005)
42 more

17 mentions without citation

Neuropilin Functions as an Essential Cell Surface Receptor.
Guo et al. (2015)
16 more