› 1ona

X-ray diffraction
2.35Å resolution

CO-CRYSTALS OF CONCANAVALIN A WITH METHYL-3,6-DI-O-(ALPHA-D-MANNOPYRANOSYL)-ALPHA-D-MANNOPYRANOSIDE

Released:
DOI: 10.2210/pdb1ona/pdb
PDB entry 1ona coloured by chain, front view.
PDB entry 1ona coloured by chain, side view.
PDB entry 1ona coloured by chain, top view.
Source organism: Canavalia ensiformis
Primary publication:
A structure of the complex between concanavalin A and methyl-3,6-di-O-(alpha-D-mannopyranosyl)-alpha-D-mannopyranoside reveals two binding modes.
Loris R, Maes D, Poortmans F, Wyns L, Bouckaert J
J Biol Chem 271 30614-8 (1996)
PMID: 8940035

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136271 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Concanavalin-A, 2nd part Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 237 amino acids
Theoretical weight: 25.62 KDa
Source organism: Canavalia ensiformis
UniProt:
  • Canonical: P02866 (Residues: 28-148; Coverage: 46%)
Sequence domains: Legume lectin domain
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: MMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand MN 4 x MN
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 59.83Å b: 64.84Å c: 125.92Å
α: 90° β: 93.87° γ: 90°
R-values:
R R work R free
0.221 0.221 0.282

Quick links

Citations

4 review citations

Do we underestimate the importance of water in cell biology?
Chaplin M. (2006)
3 more

6 mentions without citation

Overview of the Structure⁻Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi.
Barre et al. (2019)
5 more