› 1onc

X-ray diffraction
1.7Å resolution

THE REFINED 1.7 ANGSTROMS X-RAY CRYSTALLOGRAPHIC STRUCTURE OF P-30, AN AMPHIBIAN RIBONUCLEASE WITH ANTI-TUMOR ACTIVITY

Released:
DOI: 10.2210/pdb1onc/pdb
PDB entry 1onc coloured by chain, front view.
PDB entry 1onc coloured by chain, side view.
PDB entry 1onc coloured by chain, top view.
Source organism: Lithobates pipiens
Primary publication:
Refined 1.7 A X-ray crystallographic structure of P-30 protein, an amphibian ribonuclease with anti-tumor activity.
Mosimann SC, Ardelt W, James MN
J Mol Biol 236 1141-53 (1994)
PMID: 8120892

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149514 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein P-30 Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 11.85 KDa
Source organism: Lithobates pipiens
Expression system: Not provided
UniProt:
  • Canonical: P22069 (Residues: 1-104; Coverage: 100%)
Sequence domains: Pancreatic ribonuclease
Structure domains: Ribonuclease A-like domain

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 40.53Å b: 69.64Å c: 32.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.178 not available
Expression system: Not provided

Quick links

Citations

12 review citations

Cancer chemotherapy--ribonucleases to the rescue.
Leland et al. (2001)
11 more

27 mentions without citation

Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity.
Rutkoski et al. (2008)
26 more