› 1oqd

X-ray diffraction
2.6Å resolution

Crystal structure of sTALL-1 and BCMA

Released:
DOI: 10.2210/pdb1oqd/pdb
PDB entry 1oqd coloured by chain, front view.
PDB entry 1oqd coloured by chain, side view.
PDB entry 1oqd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand-receptor binding revealed by the TNF family member TALL-1.
Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, Pan CH, Martin WE, Murphy RC, Shu HB, Dai S, Zhang G
Nature 423 49-56 (2003)
PMID: 12721620

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero 108-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169692 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 13b, soluble form Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 144 amino acids
Theoretical weight: 16.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y275 (Residues: 142-285; Coverage: 51%)
Gene names: BAFF, BLYS, TALL1, TNFSF13B, TNFSF20, UNQ401/PRO738, ZTNF4
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 17 Chains: K, L, M, N, O, P, Q, R
Molecule details ›
Chains: K, L, M, N, O, P, Q, R
Length: 39 amino acids
Theoretical weight: 4.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q02223 (Residues: 8-46; Coverage: 21%)
Gene names: BCM, BCMA, TNFRSF17
Sequence domains: BCMA, TALL-1 binding

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P6322
Unit cell:
a: 232.854Å b: 232.854Å c: 212.477Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.24 0.24 0.26
Expression system: Escherichia coli

Quick links

Citations

31 review citations

Cracking the BAFF code.
Mackay et al. (2009)
30 more

6 mentions without citation

Impact of Endocytosis Mechanisms for the Receptors Targeted by the Currently Approved Antibody-Drug Conjugates (ADCs)-A Necessity for Future ADC Research and Development.
Hammood et al. (2021)
5 more