1oqn

X-ray diffraction
2.3Å resolution

Crystal structure of the phosphotyrosine binding domain (PTB) of mouse Disabled 1 (Dab1)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
PDBe Complex ID:
PDB-CPX-140208 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Disabled homolog 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 159 amino acids
Theoretical weight: 17.96 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P97318 (Residues: 25-183; Coverage: 27%)
Gene name: Dab1
Sequence domains:
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
C31 Chains: C, D
Molecule details ›
Chains: C, D
Length: 9 amino acids
Theoretical weight: 1.09 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P08592 (Residues: 755-763; Coverage: 1%)
Gene names: A4, AD1, App

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 59.106Å b: 66.481Å c: 90.528Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.246 0.246 0.303
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided