› 1oz6

X-ray diffraction
2.6Å resolution

X-ray structure of acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) with a potent platelet aggregation inhibitory activity

Released:
DOI: 10.2210/pdb1oz6/pdb
PDB entry 1oz6 coloured by chain, front view.
PDB entry 1oz6 coloured by chain, side view.
PDB entry 1oz6 coloured by chain, top view.
Source organism: Echis carinatus
Primary publication:
Structure of an acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) at 2.6 A resolution reveals a novel intermolecular interaction.
Jasti J, Paramasivam M, Srinivasan A, Singh TP
Acta Crystallogr D Biol Crystallogr 60 66-72 (2004)
PMID: 14684894

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182009 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acidic phospholipase A2 EC-I Chain: A
Molecule details ›
Chain: A
Length: 120 amino acids
Theoretical weight: 13.73 KDa
Source organism: Echis carinatus
UniProt:
  • Canonical: Q7T3S7 (Residues: 17-136; Coverage: 100%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21212
Unit cell:
a: 63.963Å b: 57.876Å c: 33.682Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.192 0.257

Quick links

Citations

2 review citations

Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis.
Kang et al. (2011)
1 more

4 mentions without citation

Catalytically Active Snake Venom PLA2 Enzymes: An Overview of Its Elusive Mechanisms of Reaction.
Castro-Amorim et al. (2023)
3 more