› 1p3h

X-ray diffraction
2.8Å resolution

Crystal Structure of the Mycobacterium tuberculosis chaperonin 10 tetradecamer

Released:
DOI: 10.2210/pdb1p3h/pdb
Model geometry
Fit model/data
PDB entry 1p3h coloured by chain, front view.
PDB entry 1p3h coloured by chain, side view.
PDB entry 1p3h coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Mycobacterium tuberculosis chaperonin 10 heptamers self-associate through their biologically active loops.
Roberts MM, Coker AR, Fossati G, Mascagni P, Coates AR, Wood SP
J Bacteriol 185 4172-85 (2003)
PMID: 12837792

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo heptamer (preferred)
homo tetradecamer
Assembly name:
PDBe Complex ID:
PDB-CPX-161972 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Co-chaperonin GroES Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N
Length: 99 amino acids
Theoretical weight: 10.68 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WPE5 (Residues: 2-100; Coverage: 99%)
Gene names: MTCY78.11, Rv3418c, cpn10, groES, groS, mopB
Sequence domains: Chaperonin 10 Kd subunit
Structure domains: GroES chaperonin

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand MPD 18 x MPD
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SRS BEAMLINE PX7.2
Spacegroup: P21
Unit cell:
a: 76.46Å b: 87.93Å c: 124.39Å
α: 90° β: 106.78° γ: 90°
R-values:
R R work R free
0.26 0.259 0.28
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

Multiple chaperonins in bacteria--why so many?
Lund PA. (2009)
2 more

5 mentions without citation

Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
van Noort et al. (2012)
4 more