› 1p5f

X-ray diffraction
1.1Å resolution

Crystal Structure of Human DJ-1

Released:
DOI: 10.2210/pdb1p5f/pdb
PDB entry 1p5f coloured by chain, front view.
PDB entry 1p5f coloured by chain, side view.
PDB entry 1p5f coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease.
Wilson MA, Collins JL, Hod Y, Ringe D, Petsko GA
Proc Natl Acad Sci U S A 100 9256-61 (2003)
PMID: 12855764

Function and Biology Details

Reaction catalysed: 
An N(6)-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H(2)O = a [protein]-L-lysine + lactate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189205 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Parkinson disease protein 7 Chain: A
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 19.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99497 (Residues: 1-189; Coverage: 100%)
Gene name: PARK7
Sequence domains: DJ-1/PfpI family
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P3121
Unit cell:
a: 75.306Å b: 75.306Å c: 75.422Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.139 0.139 0.161
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

45 review citations

Molecular pathophysiology of Parkinson's disease.
Moore et al. (2005)
44 more

31 mentions without citation

The role of cysteine oxidation in DJ-1 function and dysfunction.
Wilson MA. (2011)
30 more