› 1p7o

X-ray diffraction
2.3Å resolution

Crystal structure of phospholipase A2 (MIPLA4) from Micropechis ikaheka

Released:
DOI: 10.2210/pdb1p7o/pdb
PDB entry 1p7o coloured by chain, front view.
PDB entry 1p7o coloured by chain, side view.
PDB entry 1p7o coloured by chain, top view.
Source organism: Micropechis ikaheca
Primary publication:
Structure and function comparison of Micropechis ikaheka snake venom phospholipase A2 isoenzymes.
Lok SM, Gao R, Rouault M, Lambeau G, Gopalakrishnakone P, Swaminathan K
FEBS J 272 1211-20 (2005)
PMID: 15720395

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175090 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acidic phospholipase A2 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 124 amino acids
Theoretical weight: 14.05 KDa
Source organism: Micropechis ikaheca
UniProt:
  • Canonical: Q45Z29 (Residues: 28-141; Coverage: 92%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL40B2
Spacegroup: I41
Unit cell:
a: 88.038Å b: 88.038Å c: 262.941Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 0.274

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Citations

2 review citations

Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis.
Kang et al. (2011)
1 more

2 mentions without citation

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Rocha et al. (2021)
1 more