› 1p96

Solution NMR

Solution Structure of a Wedge-Shaped Synthetic Molecule at a Two-Base Bulge Site in DNA

Released:
DOI: 10.2210/pdb1p96/pdb
PDB entry 1p96 coloured by chain, ensemble of 10 models, front view.
PDB entry 1p96 coloured by chain, ensemble of 10 models, side view.
PDB entry 1p96 coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Solution structure of a wedge-shaped synthetic molecule at a two-base bulge site in DNA.
Hwang GS, Jones GB, Goldberg IH
Biochemistry 42 8472-83 (2003)
PMID: 12859193

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114367 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*CP*AP*CP*GP*CP*AP*GP*TP*TP*CP*GP*GP*AP*C)-3' Chain: A
Molecule details ›
Chain: A
Length: 14 nucleotides
Theoretical weight: 4.27 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*GP*TP*CP*CP*GP*AP*TP*GP*CP*GP*TP*G)-3' Chain: B
Molecule details ›
Chain: B
Length: 12 nucleotides
Theoretical weight: 3.69 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DDI 1 x DDI
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry sinulated annealing
Expression system: Not provided

Quick links

Citations

11 citation in other articles

Molecular probes of DNA bulges: functional assay and spectroscopic analysis.
Jones et al. (2007)
10 more

1 mention without citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)