1p9o

X-ray diffraction
2.3Å resolution

Crystal Structure of Phosphopantothenoylcysteine Synthetase

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + (R)-4'-phosphopantothenate + L-cysteine = AMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-190713 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphopantothenate--cysteine ligase Chains: A, B
Molecule details ›
Chains: A, B
Length: 313 amino acids
Theoretical weight: 34.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HAB8 (Residues: 1-311; Coverage: 100%)
Gene names: COAB, PPCS
Sequence domains: DNA / pantothenate metabolism flavoprotein
Structure domains: CoaB-like

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 8-BM
Spacegroup: P43212
Unit cell:
a: 73.16Å b: 73.16Å c: 281.83Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.229 0.272
Expression system: Escherichia coli