› 1pbv

X-ray diffraction
2Å resolution

SEC7 DOMAIN OF THE EXCHANGE FACTOR ARNO

Released:
DOI: 10.2210/pdb1pbv/pdb
PDB entry 1pbv coloured by chain, front view.
PDB entry 1pbv coloured by chain, side view.
PDB entry 1pbv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Sec7 domain of the Arf exchange factor ARNO.
Cherfils J, Ménétrey J, Mathieu M, Le Bras G, Robineau S, Béraud-Dufour S, Antonny B, Chardin P
Nature 392 101-5 (1998)
PMID: 9510256

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189195 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytohesin-2 Chain: A
Molecule details ›
Chain: A
Length: 195 amino acids
Theoretical weight: 22.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q99418 (Residues: 52-246; Coverage: 49%)
Gene names: ARNO, CYTH2, PSCD2, PSCD2L
Sequence domains: Sec7 domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE, ESRF
Spacegroup: P213
Unit cell:
a: 89.766Å b: 89.766Å c: 89.766Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.182 0.226
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Regulation of small GTPases by GEFs, GAPs, and GDIs.
Cherfils et al. (2013)
19 more

4 mentions without citation

Prediction of functional sites by analysis of sequence and structure conservation.
Panchenko et al. (2004)
3 more