› 1pc2

Solution NMR

Solution structure of human mitochondria fission protein Fis1

Released:
DOI: 10.2210/pdb1pc2/pdb
PDB entry 1pc2 coloured by chain, ensemble of 20 models, front view.
PDB entry 1pc2 coloured by chain, ensemble of 20 models, side view.
PDB entry 1pc2 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle.
Suzuki M, Jeong SY, Karbowski M, Youle RJ, Tjandra N
J Mol Biol 334 445-58 (2003)
PMID: 14623186

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitochondrial fission 1 protein Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y3D6 (Residues: 1-145; Coverage: 95%)
Gene names: CGI-135, FIS1, TTC11
Sequence domains:
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Distance geometry, Simulated annealing, Molecular dynamics
Expression system: Escherichia coli BL21(DE3)

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Citations

58 review citations

Mitochondrial dynamics and apoptosis.
Suen et al. (2008)
57 more

13 mentions without citation

Helix insertion into bilayers and the evolution of membrane proteins.
Renthal R. (2010)
12 more