› 1pcf

X-ray diffraction
1.74Å resolution

HUMAN TRANSCRIPTIONAL COACTIVATOR PC4 C-TERMINAL DOMAIN

Released:
DOI: 10.2210/pdb1pcf/pdb
PDB entry 1pcf coloured by chain, front view.
PDB entry 1pcf coloured by chain, side view.
PDB entry 1pcf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site.
Brandsen J, Werten S, van der Vliet PC, Meisterernst M, Kroon J, Gros P
Nat Struct Biol 4 900-3 (1997)
PMID: 9360603

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156926 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activated RNA polymerase II transcriptional coactivator p15 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 66 amino acids
Theoretical weight: 7.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P53999 (Residues: 63-127; Coverage: 51%)
Gene names: PC4, RPO2TC1, SUB1
Sequence domains: Transcriptional Coactivator p15 (PC4)
Structure domains: Transcriptional Coactivator Pc4; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P1
Unit cell:
a: 41.283Å b: 67.814Å c: 67.17Å
α: 87.69° β: 84.37° γ: 85.79°
R-values:
R R work R free
0.197 0.197 0.233
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

The general transcription machinery and general cofactors.
Thomas et al. (2006)
5 more

10 mentions without citation

The Molecular Function of PURA and Its Implications in Neurological Diseases.
Molitor et al. (2021)
9 more