› 1pd3

X-ray diffraction
2.6Å resolution

Influenza A NEP M1-binding domain

Released:
DOI: 10.2210/pdb1pd3/pdb
PDB entry 1pd3 coloured by chain, front view.
PDB entry 1pd3 coloured by chain, side view.
PDB entry 1pd3 coloured by chain, top view.
Source organism: Influenza A virus
Primary publication:
Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2).
Akarsu H, Burmeister WP, Petosa C, Petit I, Müller CW, Ruigrok RW, Baudin F
EMBO J 22 4646-55 (2003)
PMID: 12970177

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-137087 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear export protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 58 amino acids
Theoretical weight: 7.24 KDa
Source organism: Influenza A virus
Expression system: Escherichia coli
UniProt:
  • Canonical: P03508 (Residues: 59-116; Coverage: 48%)
Gene name: NS
Sequence domains: Influenza non-structural protein (NS2)
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P3221
Unit cell:
a: 82.691Å b: 82.691Å c: 61.111Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.176 0.244
Expression system: Escherichia coli

Quick links

Citations

31 review citations

Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
Dou et al. (2018)
30 more

10 mentions without citation

Emerging roles for the influenza A virus nuclear export protein (NEP).
Paterson et al. (2012)
9 more