› 1pe4

Solution NMR

SOLUTION STRUCTURE OF TOXIN CN12 FROM CENTRUROIDES NOXIUS ALFA SCORPION TOXIN ACTING ON SODIUM CHANNELS. NMR STRUCTURE

Released:
DOI: 10.2210/pdb1pe4/pdb
PDB entry 1pe4 coloured by chain, ensemble of 19 models, front view.
PDB entry 1pe4 coloured by chain, ensemble of 19 models, side view.
PDB entry 1pe4 coloured by chain, ensemble of 19 models, top view.
Source organism: Centruroides noxius
Primary publication:
NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity.
del Río-Portilla F, Hernández-Marín E, Pimienta G, Coronas FV, Zamudio FZ, Rodríguez de la Vega RC, Wanke E, Possani LD
Eur J Biochem 271 2504-16 (2004)
PMID: 15182366

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158926 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-toxin Cn12 Chain: A
Molecule details ›
Chain: A
Length: 67 amino acids
Theoretical weight: 7.15 KDa
Source organism: Centruroides noxius
UniProt:
  • Canonical: P63019 (Residues: 1-67; Coverage: 100%)
Sequence domains: Scorpion toxin-like domain
Structure domains: Knottin, scorpion toxin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing

Quick links

Citations

5 review citations

Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution.
Rodríguez de la Vega et al. (2005)
4 more