› 1pev

X-ray diffraction
2Å resolution

Crystal Structure of the Actin Interacting Protein from Caenorhabditis Elegans

Released:
DOI: 10.2210/pdb1pev/pdb
PDB entry 1pev coloured by chain, front view.
PDB entry 1pev coloured by chain, side view.
PDB entry 1pev coloured by chain, top view.
Source organism: Caenorhabditis elegans
Primary publication:
Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments.
Mohri K, Vorobiev S, Fedorov AA, Almo SC, Ono S
J Biol Chem 279 31697-707 (2004)
PMID: 15150269

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171263 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin-interacting protein 1 Chain: A
Molecule details ›
Chain: A
Length: 611 amino acids
Theoretical weight: 65.39 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q11176 (Residues: 1-611; Coverage: 100%)
Gene names: C04F6.4, unc-78
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9A
Spacegroup: P21
Unit cell:
a: 40.66Å b: 90.817Å c: 76.983Å
α: 90° β: 94.06° γ: 90°
R-values:
R R work R free
0.197 0.197 0.234
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Structure and function of WD40 domain proteins.
Xu et al. (2011)
8 more

6 mentions without citation

Functions of actin-interacting protein 1 (AIP1)/WD repeat protein 1 (WDR1) in actin filament dynamics and cytoskeletal regulation.
Ono S. (2018)
5 more