› 1pi7

Solid-state NMR

Structure of the channel-forming trans-membrane domain of Virus protein "u" (Vpu) from HIV-1

Released:
DOI: 10.2210/pdb1pi7/pdb
PDB entry 1pi7 coloured by chain, ensemble of 5 models, front view.
PDB entry 1pi7 coloured by chain, ensemble of 5 models, side view.
PDB entry 1pi7 coloured by chain, ensemble of 5 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" (Vpu) from HIV-1.
Park SH, Mrse AA, Nevzorov AA, Mesleh MF, Oblatt-Montal M, Montal M, Opella SJ
J Mol Biol 333 409-24 (2003)
PMID: 14529626

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Vpu Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 3.87 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q70625 (Residues: 1-30; Coverage: 37%)
Gene name: vpu
Sequence domains: Vpu protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SCWRL 2.1
Expression system: Escherichia coli

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Citations

41 review citations

Structure determination of membrane proteins by NMR spectroscopy.
Opella et al. (2004)
40 more

10 mentions without citation

Viroporins: structure and biological functions.
Nieva et al. (2012)
9 more