› 1pko

X-ray diffraction
1.45Å resolution

Myelin Oligodendrocyte Glycoprotein (MOG)

Released:
DOI: 10.2210/pdb1pko/pdb
PDB entry 1pko coloured by chain, front view.
PDB entry 1pko coloured by chain, side view.
PDB entry 1pko coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein.
Breithaupt C, Schubart A, Zander H, Skerra A, Huber R, Linington C, Jacob U
Proc Natl Acad Sci U S A 100 9446-51 (2003)
PMID: 12874380

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179007 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myelin-oligodendrocyte glycoprotein Chain: A
Molecule details ›
Chain: A
Length: 139 amino acids
Theoretical weight: 15.98 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q63345 (Residues: 28-152; Coverage: 57%)
Gene name: Mog
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 1 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6, null
Spacegroup: P3221
Unit cell:
a: 50.234Å b: 50.234Å c: 76.61Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.194 0.219
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Multiple sclerosis.
Hafler et al. (2005)
11 more

12 mentions without citation

A B Cell-Driven Autoimmune Pathway Leading to Pathological Hallmarks of Progressive Multiple Sclerosis in the Marmoset Experimental Autoimmune Encephalomyelitis Model.
't Hart et al. (2017)
11 more