› 1pkq

X-ray diffraction
3Å resolution

Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex

Released:
DOI: 10.2210/pdb1pkq/pdb
PDB entry 1pkq coloured by chain, front view.
PDB entry 1pkq coloured by chain, side view.
PDB entry 1pkq coloured by chain, top view.
Source organisms:
Primary publication:
Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein.
Breithaupt C, Schubart A, Zander H, Skerra A, Huber R, Linington C, Jacob U
Proc Natl Acad Sci U S A 100 9446-51 (2003)
PMID: 12874380

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-212334 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
(8-18C5) chimeric Fab, light chain Chains: A, F
Molecule details ›
Chains: A, F
Length: 241 amino acids
Theoretical weight: 26.15 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins
(8-18C5) chimeric Fab, heavy chain Chains: B, G
Molecule details ›
Chains: B, G
Length: 252 amino acids
Theoretical weight: 26.68 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Myelin-oligodendrocyte glycoprotein Chains: E, J
Molecule details ›
Chains: E, J
Length: 139 amino acids
Theoretical weight: 15.93 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q63345 (Residues: 28-152; Coverage: 57%)
Gene name: Mog
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P21
Unit cell:
a: 124.48Å b: 40Å c: 134.2Å
α: 90° β: 107.75° γ: 90°
R-values:
R R work R free
0.25 0.25 0.319
Expression system: Escherichia coli

Quick links

Citations

14 review citations

Multiple sclerosis.
Hafler et al. (2005)
13 more

10 mentions without citation

Antibody-protein interactions: benchmark datasets and prediction tools evaluation.
Ponomarenko et al. (2007)
9 more