› 1pnn

X-ray diffraction
2.5Å resolution

PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA

Released:
DOI: 10.2210/pdb1pnn/pdb
PDB entry 1pnn coloured by chain, front view.
PDB entry 1pnn coloured by chain, side view.
PDB entry 1pnn coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex.
Betts L, Josey JA, Veal JM, Jordan SR
Science 270 1838-41 (1995)
PMID: 8525381

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114396 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
PNA (NH2-P(*C*T*C*T*T*C*T*T*C-HIS-GLY-SER-SER-GLY-HIS-C*T*T*C*T*T*C*T*C)-COOH) Chains: A, C
Molecule details ›
Chains: A, C
Length: 24 nucleotides
Theoretical weight: 5.32 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(GP*AP*AP*GP*AP*AP*GP*AP*G)-3') Chains: B, D
Molecule details ›
Chains: B, D
Length: 9 nucleotides
Theoretical weight: 2.84 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1, null
Spacegroup: P6522
Unit cell:
a: 73.38Å b: 73.38Å c: 141.28Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.187 0.235
Expression system: Not provided

Quick links

Citations

31 review citations

Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future.
Ray et al. (2000)
30 more

7 mentions without citation

Antibacterial Peptide Nucleic Acids-Facts and Perspectives.
Wojciechowska et al. (2020)
6 more