› 1poa

X-ray diffraction
1.5Å resolution

INTERFACIAL CATALYSIS: THE MECHANISM OF PHOSPHOLIPASE A2

Released:
DOI: 10.2210/pdb1poa/pdb
PDB entry 1poa coloured by chain, front view.
PDB entry 1poa coloured by chain, side view.
PDB entry 1poa coloured by chain, top view.
Source organism: Naja atra
Primary publication:
Interfacial catalysis: the mechanism of phospholipase A2.
Scott DL, White SP, Otwinowski Z, Yuan W, Gelb MH, Sigler PB
Science 250 1541-6 (1990)
PMID: 2274785

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132752 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acidic phospholipase A2 1 Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 13.15 KDa
Source organism: Naja atra
Expression system: Not provided
UniProt:
  • Canonical: P00598 (Residues: 28-145; Coverage: 94%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I4
Unit cell:
a: 93Å b: 93Å c: 22.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.143 0.143 not available
Expression system: Not provided

Quick links

Citations

48 review citations

The expanding superfamily of phospholipase A(2) enzymes: classification and characterization.
Six et al. (2000)
47 more

21 mentions without citation

Anticoagulant proteins from snake venoms: structure, function and mechanism.
Kini RM. (2006)
20 more