› 1pqq

Solution NMR

NMR Structure of a Cyclic Polyamide-DNA Complex

Released:
DOI: 10.2210/pdb1pqq/pdb
PDB entry 1pqq coloured by chain, ensemble of 21 models, front view.
PDB entry 1pqq coloured by chain, ensemble of 21 models, side view.
PDB entry 1pqq coloured by chain, ensemble of 21 models, top view.
Source organism: Synthetic construct
Primary publication:
NMR structure of a cyclic polyamide-DNA complex.
Zhang Q, Dwyer TJ, Tsui V, Case DA, Cho J, Dervan PB, Wemmer DE
J Am Chem Soc 126 7958-66 (2004)
PMID: 15212545

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114401 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*CP*GP*CP*TP*AP*AP*CP*AP*GP*GP*C)-3' Chain: A
Molecule details ›
Chain: A
Length: 11 nucleotides
Theoretical weight: 3.34 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*GP*CP*CP*TP*GP*TP*TP*AP*GP*CP*G)-3' Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.37 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CYE 1 x CYE
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

1 review citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
18 other articles

1 mention without citation

Investigation and improvement of DNA cleavage models of polyamide + Cu(II) nuclease + OOH- ligands bound to DNA.
Yue et al. (2010)