› 1prh

X-ray diffraction
3.5Å resolution

THE X-RAY CRYSTAL STRUCTURE OF THE MEMBRANE PROTEIN PROSTAGLANDIN H2 SYNTHASE-1

Released:
DOI: 10.2210/pdb1prh/pdb
PDB entry 1prh coloured by chain, front view.
PDB entry 1prh coloured by chain, side view.
PDB entry 1prh coloured by chain, top view.
Source organism: Ovis aries
Primary publication:
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.
Picot D, Loll PJ, Garavito RM
Nature 367 243-9 (1994)
PMID: 8121489

Function and Biology Details

Reaction catalysed: 
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138844 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin G/H synthase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 554 amino acids
Theoretical weight: 63.87 KDa
Source organism: Ovis aries
Expression system: Not provided
UniProt:
  • Canonical: P05979 (Residues: 33-586; Coverage: 96%)
Gene names: COX1, PTGS1
Sequence domains: Animal haem peroxidase
Structure domains:

Ligands and Environments


Cofactor: Ligand HEM 2 x HEM
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: I222
Unit cell:
a: 99.4Å b: 210.3Å c: 233.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.267 0.267 0.316
Expression system: Not provided

Quick links

Citations

189 review citations

Cyclooxygenases 1 and 2.
Vane et al. (1998)
188 more

13 mentions without citation

Overview of protein structural and functional folds.
Sun et al. (2004)
12 more